Understanding the Cellular Ecosystems that Govern Health and Disease
Every tissue is built from dynamic communities of epithelial, immune, stromal, vascular, and neural cells that communicate to maintain tissue homeostasis and respond to injury and disease. Understanding these multicellular ecosystems is essential for developing new therapies for cancer, immune disorders, and regenerative medicine.
The Roose lab investigates how these cellular ecosystems govern tissue function by integrating patient-derived organoids and assembloids with multimodal molecular profiling, computational biology, and functional perturbation. Our goal is to uncover how cell fitness, stem cell behavior, immune responses, and tumor evolution emerge from interactions among diverse cell types rather than from individual cells alone.
Cancer Biology: What are the cellular ecosystems that regulate tumor fitness and therapeutic response?
Immune Biology: Immune cell fitness and the mechanisms that regulate inflammation, cancer immunity, and autoimmunity
Stem Cell & Regenerative Biology: We investigate stem cell behavior using patient-derived organoids and human model systems.
From patients to mechanisms. We integrate patient-derived human model systems, multimodal molecular profiling, computational biology, and functional perturbation to uncover how multicellular ecosystems regulate health and disease. This discovery pipeline identifies causal mechanisms and reveals new therapeutic opportunities.
Collaborative Discovery. To accelerate scientific discovery, Dr. Roose has built collaborative research initiatives that connect experimental biology, computational science, and clinical research to better understand human disease. He is co-founder of the UCSF Bakar ImmunoX Initiative, founder of the Organoid Core, and co-founder of the UCSF AutoImmunoProfiler Initiative.
