Welcome to the Roose Lab
The Roose lab studies how cell fitness and cell fate decisions are shaped by cellular networks in healthy tissues, cancer, and immune-mediated disease. By combining organoids, single-cell technologies, engineered multicellular systems, and complementary mouse models for T cell immunology, we deconstruct and reconstruct (human) tissue ecosystems to uncover mechanisms that drive tissue homeostasis, disease progression, and therapy response. The Roose lab is a rich training environment. As a group leader, Dr. Roose has thus far mentored 7 graduate students, 22 postdoctoral fellows, 15 undergraduate students, 19 staff technicians, and numerous rotation students.
Message from Jeroen Roose
I received my PhD training in The Netherlands in the laboratory of Dr. Hans Clevers, studying Wnt signaling and cancer, followed by postdoctoral training at University of California, San Francisco with Dr. Arthur Weiss investigating Ras signaling in lymphocytes. These experiences shaped my long-standing interest in cellular fitness across tissues and disease, and I established my independent laboratory at UCSF in 2007, where I currently serve as Professor and Vice Chair of Anatomy. I am a co-founder of the https://immunox.ucsf.edu/ and founder of UCSF Organoid D2B core (link to Organoid tab).
Connect with Dr. Roose on Linkedin
We are grateful for past and current the financial support from the following agencies:
- NIH (NIAID, NCI, NHLBI)
- Foundations (Mark Foundation for Cancer Research, Cancer League, Lopker Foundation, Shorenstein Pancreatic Cancer Fund)
- UCSF Programs (Bakar ImmunoX CoProject, Bakar Aging Research Institute, PBBR)
- Industry (AutoImmuno Profiler Program with Eli Lilly, SRA with Tahoe TX)
Other Roose Lab websites:
Roose Lab in the Anatomy Department
Roose Lab in the UCSF BMS Program
Roose Lab in the UCSF Helen Diller Family Comprehensive Cancer Center